Development of Multimodal Polymersomes for Image-Guided Drug Delivery Applications (MULTIPOLE)

Funded by TÜBİTAK 2531 Bilateral Cooperation Programme with the DAAD German Academic Exchange Service

Grant Nr. 124N100, 15.01.2025 - 15.01.2027

Project title: Development of Multimodal Polymersomes for Image-Guided Drug Delivery Applications (MULTIPOLE)

Principal Investigator: Banu İyisan

Project Summary: The aim of this project is to develop an innovative multifunctional nanocarrier system, which integrates pH-sensitive polymersomes with beta-cyclodextrin coated superparamagnetic iron oxide nanoparticles (SPIONs) and the anticancer drug doxorubicin. The primary goal is to create a polymeric nanoacarrier system that effectively responds to pH changes for controlled drug release, leveraging the magnetic resonance imaging (MRI) capabilities of SPIONs for diagnostic applications. 

In this project, we will cooperate with Dr. Dietmar Appelhans from the  Leibniz-Institut for Polymer Research (IPF) and strengthen our ongoing collaborations with Prof. Brigitte Voit’s group at IPF. This cooperation will not only advance our research in theranostic nanocarriers but also support researcher mobility between BIND LAB and IPF.

Additionally, this project will complement our TÜBİTAK 1004 project as part of the Nöroteknolojik Çözümler Platformu (https://ntcp.bogazici.edu.tr/) where we are developing multimodal nanocapsules for Magnetic Particle Imaging (MPI) and Magnetic Resonance Imaging (MRI) systems for neuroimaging.